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The inflammatory response of human pancreatic cancer samples compared to normal controls.

ABSTRACT: Pancreatic ductal adenocarcinoma (PDAC) is a poor prognosis cancer with an aggressive growth profile that is often diagnosed at late stage and that has few curative or therapeutic options. PDAC growth has been linked to alterations in the pancreas microbiome, which could include the presence of the fungus Malassezia. We used RNA-sequencing to compare 14 matched tumor and normal (tumor adjacent) pancreatic cancer samples and found Malassezia RNA in both the PDAC and normal tissues. Although the presence of Malassezia was not correlated with tumor growth, a set of immune- and inflammatory-related genes were up-regulated in the PDAC compared to the normal samples, suggesting that they are involved in tumor progression. Gene set enrichment analysis suggests that activation of the complement cascade pathway and inflammation could be involved in pro PDAC growth.

SUBMITTER: Brayer KJ

PROVIDER: S-EPMC10619777 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature

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The inflammatory response of human pancreatic cancer samples compared to normal controls.

Brayer Kathryn J KJ Hanson Joshua A JA Cingam Shashank S Martinez Cathleen C Ness Scott A SA Rabinowitz Ian I

PloS one 20231101 11

Pancreatic ductal adenocarcinoma (PDAC) is a poor prognosis cancer with an aggressive growth profile that is often diagnosed at late stage and that has few curative or therapeutic options. PDAC growth has been linked to alterations in the pancreas microbiome, which could include the presence of the fungus Malassezia. We used RNA-sequencing to compare 14 matched tumor and normal (tumor adjacent) pancreatic cancer samples and found Malassezia RNA in both the PDAC and normal tissues. Although the p ...[more]

PMID: 37910468

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