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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of human normal pancreas samples, and samples from patients with chronic pancreatitis, pancreatic cancer and metastatic pancreatic cancer

ABSTRACT: This dataset presents the gene expression profiles of 36 frozen pancreas samples. RNA from 9 normal pancreas samples, 9 samples from patients with chronic pancreatitis, 9 samples from patients with pancreatic cancer and 9 samples from patients with metastatic pancreatic cancer was extracted and hybridized individually to Affymetrix HG_U95Av2 microarray chips. The data present a gene expression profile of the pancreas in normal and diseased states and has been used to identify genes which may play an important role in disease of the pancreas.

ORGANISM(S): Homo sapiens

DISEASE(S): normal

SUBMITTER: Amir Abdollahi

PROVIDER: E-EMBL-6 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Transcriptional network governing the angiogenic switch in human pancreatic cancer.

Abdollahi Amir A Schwager Christian C Kleeff Jörg J Esposito Irene I Domhan Sophie S Peschke Peter P Hauser Kai K Hahnfeldt Philip P Hlatky Lynn L Debus Jürgen J Peters Jeffrey M JM Friess Helmut H Folkman Judah J Huber Peter E PE

Proceedings of the National Academy of Sciences of the United States of America 20070724 31

A shift of the angiogenic balance to the proangiogenic state, termed the "angiogenic switch," is a hallmark of cancer progression. Here we devise a strategy for identifying genetic participants of the angiogenic switch based on inverse regulation of genes in human endothelial cells in response to key endogenous pro- and antiangiogenic proteins. This approach reveals a global network pattern for vascular homeostasis connecting known angiogenesis-related genes with previously unknown signaling com ...[more]

PMID: 17652168

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