Dataset Information

Screening of Crucial Differentially-Methylated/Expressed Genes for Alzheimer's Disease.

ABSTRACT: Background: We aimed to make an integrated analysis of published transcriptome and DNA methylation dataset to ascertain the key differentially methylated and differentially expressed genes for Alzherimer's disease (AD). Methods: Two gene expression microarrays and 1 gene methylation microarray were downloaded for identification of differentially expressed genes and differentially methylated genes. Then, we used various biological information databases to annotate the functions of the differentially-methylated/expressed genes, and screen out key genes and important signaling pathways. Finally, we validate the differentially-methylated/expressed genes in the additional online datasets and in blood from AD patients.Results: A total of 8 hub hypomethylated-high expression genes were obtained, including Rac family small GTPase 2, FGR proto-oncogene, Src family tyrosine kinase, LYN proto-oncogene, Src family tyrosine kinase, protein kinase C delta, myosin IF, integrin subunit alpha 5, semaphorin 4D, and growth arrest specific protein 7. Some enriched signaling pathways of hypomethylated-high expression genes were identified, including regulation of actin cytoskeleton, chemokine signaling pathway, Fc gamma R-mediated phagocytosis, and axon guidance. Conclusion: Differentially-methylated/expressed genes are likely to be associated with AD.

SUBMITTER: Qiu H

PROVIDER: S-EPMC10624077 | biostudies-literature | 2022 Jan-Dec

REPOSITORIES: biostudies-literature

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Screening of Crucial Differentially-Methylated/Expressed Genes for Alzheimer's Disease.

Qiu Haiyuan H Weng Qiuyan Q

American journal of Alzheimer's disease and other dementias 20220101

<b>Background:</b> We aimed to make an integrated analysis of published transcriptome and DNA methylation dataset to ascertain the key differentially methylated and differentially expressed genes for Alzherimer's disease (AD). <b>Methods:</b> Two gene expression microarrays and 1 gene methylation microarray were downloaded for identification of differentially expressed genes and differentially methylated genes. Then, we used various biological information databases to annotate the functions of t ...[more]

PMID: 35848539

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Dataset Information

Screening of Crucial Differentially-Methylated/Expressed Genes for Alzheimer's Disease.

Publications

Screening of Crucial Differentially-Methylated/Expressed Genes for Alzheimer's Disease.

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