Ontology highlight
ABSTRACT:
SUBMITTER: Li C
PROVIDER: S-EPMC10625127 | biostudies-literature | 2023 Nov
REPOSITORIES: biostudies-literature
Li Caijuan C Lin Yingqi Y Chen Yizhi Y Song Xichen X Zheng Xiao X Li Jiawei J He Jun J Chen Xiusheng X Huang Chunhui C Wang Wei W Wu Jianhao J Wu Jiaxi J Gao Jiale J Tu Zhuchi Z Li Xiao-Jiang XJ Yan Sen S Li Shihua S
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 20230908 31
Accumulation of misfolded proteins leads to many neurodegenerative diseases that can be treated by lowering or removing mutant proteins. Huntington's disease (HD) is characterized by the intracellular accumulation of mutant huntingtin (mHTT) that can be soluble and aggregated in the central nervous system and causes neuronal damage and death. Here, an intracellular antibody (intrabody) fragment is generated that can specifically bind mHTT and link to the lysosome for degradation. It is found tha ...[more]