Ontology highlight
ABSTRACT:
SUBMITTER: Jeong H
PROVIDER: S-EPMC2940108 | biostudies-literature | 2009 Apr
REPOSITORIES: biostudies-literature
Jeong Hyunkyung H Then Florian F Melia Thomas J TJ Mazzulli Joseph R JR Cui Libin L Savas Jeffrey N JN Voisine Cindy C Paganetti Paolo P Tanese Naoko N Hart Anne C AC Yamamoto Ai A Krainc Dimitri D
Cell 20090401 1
Huntington's disease (HD) is an incurable neurodegenerative disease caused by neuronal accumulation of the mutant protein huntingtin. Improving clearance of the mutant protein is expected to prevent cellular dysfunction and neurodegeneration in HD. We report here that such clearance can be achieved by posttranslational modification of the mutant Huntingtin (Htt) by acetylation at lysine residue 444 (K444). Increased acetylation at K444 facilitates trafficking of mutant Htt into autophagosomes, s ...[more]