Ontology highlight
ABSTRACT:
SUBMITTER: Rosso I
PROVIDER: S-EPMC10625592 | biostudies-literature | 2023 Nov
REPOSITORIES: biostudies-literature
Rosso Ilaria I Jones-Weinert Corey C Rossiello Francesca F Cabrini Matteo M Brambillasca Silvia S Munoz-Sagredo Leonel L Lavagnino Zeno Z Martini Emanuele E Tedone Enzo E Garre' Massimiliano M Aguado Julio J Parazzoli Dario D Mione Marina M Shay Jerry W JW Mercurio Ciro C d'Adda di Fagagna Fabrizio F
Nature communications 20231104 1
Alternative lengthening of telomeres (ALT) is a telomere maintenance mechanism activated in ~10-15% of cancers, characterized by telomeric damage. Telomeric damage-induced long non-coding RNAs (dilncRNAs) are transcribed at dysfunctional telomeres and contribute to telomeric DNA damage response (DDR) activation and repair. Here we observed that telomeric dilncRNAs are preferentially elevated in ALT cells. Inhibition of C-rich (teloC) dilncRNAs with antisense oligonucleotides leads to DNA replica ...[more]