Ontology highlight
ABSTRACT:
SUBMITTER: Tangudu NK
PROVIDER: S-EPMC10634888 | biostudies-literature | 2023 Oct
REPOSITORIES: biostudies-literature
Tangudu Naveen Kumar NK Grumet Alexandra N AN Fang Richard R Buj Raquel R Cole Aidan R AR Uboveja Apoorva A Amalric Amandine A Yang Baixue B Huang Zhentai Z Happe Cassandra C Sun Mai M Gelhaus Stacy L SL MacDonald Matthew L ML Hempel Nadine N Snyder Nathaniel W NW Kedziora Katarzyna M KM Valvezan Alexander J AJ Aird Katherine M KM
bioRxiv : the preprint server for biology 20241024
DNA damage and cellular metabolism exhibit a complex interplay characterized by bidirectional feedback mechanisms. Key mediators of the DNA damage response and cellular metabolic regulation include Ataxia Telangiectasia and Rad3-related protein (ATR) and the mechanistic Target of Rapamycin Complex 1 (mTORC1), respectively. Previous studies have established ATR as a regulatory upstream factor of mTORC1 during replication stress; however, the precise mechanisms by which mTORC1 is activated in this ...[more]