Ontology highlight
ABSTRACT:
SUBMITTER: Yuan M
PROVIDER: S-EPMC10636607 | biostudies-literature | 2023 Oct
REPOSITORIES: biostudies-literature
Yuan Meng M Feng Ziqi Z Lv Huibin H So Natalie N Shen Ivana R IR Tan Timothy J C TJC Teo Qi Wen QW Ouyang Wenhao O WO Talmage Logan L Wilson Ian A IA Wu Nicholas C NC
Cell reports 20230930 10
The ability of the human immune system to generate antibodies to any given antigen can be strongly influenced by immunoglobulin V-gene allelic polymorphisms. However, previous studies have provided only limited examples. Therefore, the prevalence of this phenomenon has been unclear. By analyzing >1,000 publicly available antibody-antigen structures, we show that many V-gene allelic polymorphisms in antibody paratopes are determinants for antibody binding activity. Biolayer interferometry experim ...[more]