Herp regulates intracellular survival of Mycobacterium tuberculosis H37Ra in macrophages by regulating reactive oxygen species-mediated autophagy.
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ABSTRACT: Importance
Several studies have suggested that endoplasmic reticulum (ER) stress is important in the pathogenesis of infectious diseases; however, the precise function of ER stress regulation and the role of Herp as a regulator in Mtb H37Ra-induced ER stress remain elusive. Therefore, our study investigated ER stress and autophagy associated with Herp expression in Mycobacterium tuberculosis-infected macrophages to determine the role of Herp in the pathogenesis of tuberculosis.
SUBMITTER: Son S-H
PROVIDER: S-EPMC10653826 | biostudies-literature | 2023 Oct
REPOSITORIES: biostudies-literature
Publications
Herp regulates intracellular survival of <i>Mycobacterium tuberculosis</i> H37Ra in macrophages by regulating reactive oxygen species-mediated autophagy.
Son Sang-Hun S-H Lee Junghwan J Cho Soo-Na S-N Choi Ji-Ae J-A Kim Jaewhan J Nguyen Tam Doan TD Lee Seong-Ahn S-A Son Doyi D Song Chang-Hwa C-H
mBio 20231006 5
<h4>Importance</h4>Several studies have suggested that endoplasmic reticulum (ER) stress is important in the pathogenesis of infectious diseases; however, the precise function of ER stress regulation and the role of Herp as a regulator in Mtb H37Ra-induced ER stress remain elusive. Therefore, our study investigated ER stress and autophagy associated with Herp expression in <i>Mycobacterium tuberculosis</i>-infected macrophages to determine the role of Herp in the pathogenesis of tuberculosis. ...[more]
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