Ontology highlight
ABSTRACT:
SUBMITTER: Liu F
PROVIDER: S-EPMC6191460 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Liu Feng F Chen Jianxia J Wang Peng P Li Haohao H Zhou Yilong Y Liu Haipeng H Liu Zhonghua Z Zheng Ruijuan R Wang Lin L Yang Hua H Cui Zhenling Z Wang Fei F Huang Xiaochen X Wang Jie J Sha Wei W Xiao Heping H Ge Baoxue B
Nature communications 20181016 1
Tuberculosis (TB) caused by Mycobacterium tuberculosis (Mtb) kills millions every year, and there is urgent need to develop novel anti-TB agents due to the fast-growing of drug-resistant TB. Although autophagy regulates the intracellular survival of Mtb, the role of calcium (Ca<sup>2+</sup>) signaling in modulating autophagy during Mtb infection remains largely unknown. Here, we show that microRNA miR-27a is abundantly expressed in active TB patients, Mtb-infected mice and macrophages. The targe ...[more]