Ontology highlight
ABSTRACT:
SUBMITTER: Ringsevjen H
PROVIDER: S-EPMC10658193 | biostudies-literature | 2023
REPOSITORIES: biostudies-literature
Ringsevjen Håvard H Egbenya Daniel Lawer DL Bieler Malte M Davanger Svend S Hussain Suleman S
Frontiers in molecular neuroscience 20231106
The activity-regulated cytoskeleton-associated protein (Arc/Arg3.1) is a neuron-specific immediate early gene (IEG) product. The protein regulates synaptic strength through modulation of spine density and morphology, AMPA receptor endocytosis, and as being part of a retrovirus-like inter-cellular communication mechanism. However, little is known about the detailed subsynaptic localization of the protein, and especially its possible presynaptic localization. In the present study, we provide novel ...[more]