Comparative transcriptomics reveals human-specific cortical features.
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ABSTRACT:
SUBMITTER: Jorstad NL
PROVIDER: S-EPMC10659116 | biostudies-literature | 2023 Oct
REPOSITORIES: biostudies-literature
Publications
Comparative transcriptomics reveals human-specific cortical features.
Jorstad Nikolas L NL Song Janet H T JHT Exposito-Alonso David D Suresh Hamsini H Castro-Pacheco Nathan N Krienen Fenna M FM Yanny Anna Marie AM Close Jennie J Gelfand Emily E Long Brian B Seeman Stephanie C SC Travaglini Kyle J KJ Basu Soumyadeep S Beaudin Marc M Bertagnolli Darren D Crow Megan M Ding Song-Lin SL Eggermont Jeroen J Glandon Alexandra A Goldy Jeff J Kiick Katelyn K Kroes Thomas T McMillen Delissa D Pham Trangthanh T Rimorin Christine C Siletti Kimberly K Somasundaram Saroja S Tieu Michael M Torkelson Amy A Feng Guoping G Hopkins William D WD Höllt Thomas T Keene C Dirk CD Linnarsson Sten S McCarroll Steven A SA Lelieveldt Boudewijn P BP Sherwood Chet C CC Smith Kimberly K Walsh Christopher A CA Dobin Alexander A Gillis Jesse J Lein Ed S ES Hodge Rebecca D RD Bakken Trygve E TE
Science (New York, N.Y.) 20231013 6667
The cognitive abilities of humans are distinctive among primates, but their molecular and cellular substrates are poorly understood. We used comparative single-nucleus transcriptomics to analyze samples of the middle temporal gyrus (MTG) from adult humans, chimpanzees, gorillas, rhesus macaques, and common marmosets to understand human-specific features of the neocortex. Human, chimpanzee, and gorilla MTG showed highly similar cell-type composition and laminar organization as well as a large shi ...[more]
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