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Selection of experience for memory by hippocampal sharp wave ripples.

ABSTRACT: A general wisdom is that experiences need to be tagged during learning for further consolidation. However, brain mechanisms that select experiences for lasting memory are not known. Combining large-scale neural recordings with a novel application of dimensionality reduction techniques, we observed that successive traversals in the maze were tracked by continuously drifting populations of neurons, providing neuronal signatures of both places visited and events encountered (trial number). When the brain state changed during reward consumption, sharp wave ripples (SPW-Rs) occurred on some trials and their unique spike content most often decoded the trial in which they occurred. In turn, during post-experience sleep, SPW-Rs continued to replay those trials that were reactivated most frequently during awake SPW-Rs. These findings suggest that replay content of awake SPW-Rs provides a tagging mechanism to select aspects of experience that are preserved and consolidated for future use.

SUBMITTER: Yang W

PROVIDER: S-EPMC10659301 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature

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Selection of experience for memory by hippocampal sharp wave ripples.

Yang Wannan W Sun Chen C Huszár Roman R Hainmueller Thomas T Buzsáki György G

bioRxiv : the preprint server for biology 20231108

A general wisdom is that experiences need to be tagged during learning for further consolidation. However, brain mechanisms that select experiences for lasting memory are not known. Combining large-scale neural recordings with a novel application of dimensionality reduction techniques, we observed that successive traversals in the maze were tracked by continuously drifting populations of neurons, providing neuronal signatures of both places visited and events encountered (trial number). When the ...[more]

PMID: 37987008

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