Ontology highlight
ABSTRACT:
SUBMITTER: Fu Y
PROVIDER: S-EPMC10663520 | biostudies-literature | 2023 Nov
REPOSITORIES: biostudies-literature
Fu Yuhui Y Ding Binbin B Liu Xiaoxia X Zhao Shangang S Chen Fang F Li Linsen L Zhu Yi Y Zhao Jingxuan J Yuan Zhen Z Shen Yafeng Y Yang Chaofeng C Shao Mengle M Chen She S Bickel Perry E PE Zhong Qing Q
Cell discovery 20231121 1
Lipid droplets (LDs) are dynamic lipid storage organelles that can sense and respond to changes in systemic energy balance. The size and number of LDs are controlled by complex and delicate mechanisms, among which, whether and which SNARE proteins mediate LD fusion, and the mechanisms governing this process remain poorly understood. Here we identified a SNARE complex, syntaxin 18 (STX18)-SNAP23-SEC22B, that is recruited to LDs to mediate LD fusion. STX18 targets LDs with its transmembrane domain ...[more]