Ontology highlight
ABSTRACT:
SUBMITTER: Ma C
PROVIDER: S-EPMC3087822 | biostudies-literature | 2011 May
REPOSITORIES: biostudies-literature
Nature structural & molecular biology 20110417 5
During the priming step that leaves synaptic vesicles ready for neurotransmitter release, the SNARE syntaxin-1 transitions from a closed conformation that binds Munc18-1 tightly to an open conformation within the highly stable SNARE complex. Control of this conformational transition is important for brain function, but the underlying mechanism is unknown. NMR and fluorescence experiments now show that the Munc13-1 MUN domain, which plays a central role in vesicle priming, markedly accelerates th ...[more]