Therapeutic ultrasound-enhanced immune checkpoint inhibitor therapy.
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ABSTRACT:
SUBMITTER: Yuan J
PROVIDER: S-EPMC10664841 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
Publications
Therapeutic ultrasound-enhanced immune checkpoint inhibitor therapy.
Yuan Jinyun J Ye Dezhuang D Chen Si S Chen Hong H
Frontiers in physics 20210324
Immune checkpoint inhibitors (ICIs) are designed to reinvigorate antitumor immune responses by interrupting inhibitory signaling pathways and promoting the immune-mediated elimination of malignant cells. Although ICI therapy has transformed the landscape of cancer treatment, only a subset of patients achieve a complete response. Focused ultrasound (FUS) is a noninvasive, nonionizing, deep penetrating focal therapy that has great potential to improve the efficacy of ICIs in solid tumors. Five FUS ...[more]
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