Ontology highlight
ABSTRACT:
SUBMITTER: Ma Q
PROVIDER: S-EPMC10684575 | biostudies-literature | 2023 Nov
REPOSITORIES: biostudies-literature
Ma Qinmei Q Yu Jialin J Liu Li L Ma Xiaoyan X Zhang Jiaxue J Zhang Jiamei J Wang Xiaoping X Deng Guangcun G Wu Xiaoling X
Cell death discovery 20231128 1
Tumor necrosis factor receptor-associated factor 6 (TRAF6) is an E3 ubiquitin ligase that is extensively involved in the autophagy process by interacting with diverse autophagy initiation and autophagosome maturation molecules. However, whether TRAF6 interacts with lysosomal proteins to regulate Mycobacterium-induced autophagy has not been completely characterized. Herein, the present study showed that TRAF6 interacted with lysosomal key proteins Rab7 through RING domain which caused Rab7 ubiqui ...[more]