Ontology highlight
ABSTRACT:
SUBMITTER: Chandra P
PROVIDER: S-EPMC4635374 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Chandra Pallavi P Ghanwat Swapnil S Matta Sumit Kumar SK Yadav Swati Seth SS Mehta Mansi M Siddiqui Zaved Z Singh Amit A Kumar Dhiraj D
Scientific reports 20151106
Here we report a novel regulatory mechanism for autophagy-mediated degradation of Mycobacterium tuberculosis (Mtb) and specific strategy exploited by the virulent Mtb to evade it. We show while both avirulent (H37Ra) and virulent (H37Rv) mycobacteria could readily localize to autophagosomes, their maturation into autolysosomes (flux) was significantly inhibited by the latter strain. The inhibition of autophagy flux by the virulent strain was highly selective, as it did not perturb the basal auto ...[more]