Functional characterization of OXA-57, a class D beta-lactamase from Burkholderia pseudomallei.
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ABSTRACT:
SUBMITTER: Keith KE
PROVIDER: S-EPMC1068585 | biostudies-literature | 2005 Apr
REPOSITORIES: biostudies-literature
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Functional characterization of OXA-57, a class D beta-lactamase from Burkholderia pseudomallei.
Keith Karen E KE Oyston Petra C PC Crossett Ben B Fairweather Neil F NF Titball Richard W RW Walsh Timothy R TR Brown Katherine A KA
Antimicrobial agents and chemotherapy 20050401 4
Class D beta-lactamase OXA-57 was identified in a range of isolates of Burkholderia pseudomallei and Burkholderia thailandensis. Comparative kinetic analyses of wild-type and mutant forms of B. pseudomallei OXA-57 are reported. Implications of these data for beta-lactam resistance and the proposed role of Ser-104 in beta-lactam hydrolysis are discussed. ...[more]
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