Dataset Information

Validation of a German-language modified Rankin Scale structured telephone interview at 3 months in a real-life stroke cohort.

ABSTRACT:

Background

The modified Rankin scale (mRS) at 3 months is established as the primary outcome measure in clinical stroke trials. Traditionally, the mRS is assessed through an unstructured face-to-face interview. This approach can be labor-intensive and lead to suboptimal inter-rater reliability. Recently, the Covid-19 pandemic made face-to-face contact even more challenging. To address these issues, we developed and validated a structured German-language questionnaire for mRS testing by telephone.

Methods

In this prospective cohort study, we compared the mRS testing results of the standard face-to-face interview with those obtained in a structured interview by telephone using Cohen's Kappa.

Results

At our tertiary care stroke center, we included 108 patients who underwent both assessments. In 80.6% of cases (87/108) face-to-face and telephone interview reached identical scores. Linear weighted Kappa was 0.82 (p < 0.001). Unweighted Kappa for dichotomized mRS between fair (0-2) and poor (3-6) functional outcome was κ = 0.97 (p < 0.001).

Conclusions

Our study validates the use of the German-language structured telephone interview as a reliable instrument for the use in clinical trials. We encourage others to utilize the questionnaire. It is available as an Appendix (Additional file 1) to this publication.

SUBMITTER: Milles LS

PROVIDER: S-EPMC10687899 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature

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Publications

Validation of a German-language modified Rankin Scale structured telephone interview at 3 months in a real-life stroke cohort.

Milles Lennart Steffen LS Pommeranz Doreen D Chae Woon Hyung WH Kühne Escolà Jordi J Kleinschnitz Christoph C Köhrmann Martin M Frank Benedikt B

Neurological research and practice 20231130 1

<h4>Background</h4>The modified Rankin scale (mRS) at 3 months is established as the primary outcome measure in clinical stroke trials. Traditionally, the mRS is assessed through an unstructured face-to-face interview. This approach can be labor-intensive and lead to suboptimal inter-rater reliability. Recently, the Covid-19 pandemic made face-to-face contact even more challenging. To address these issues, we developed and validated a structured German-language questionnaire for mRS testing by t ...[more]

PMID: 38031129

Similar Datasets

Project description:ObjectiveTo determine the predictive value of discharge destination as a surrogate for defining unfavorable outcome at 3- and 12-months poststroke.DesignAnalysis of the prospectively collected data from a randomized, placebo-controlled trial in patients with ischemic stroke presenting within 3 hours of symptom onset.SettingPost hoc analysis of patients recruited in a clinical trial.ParticipantsPatients (N=530) discharged alive from the hospital after ischemic stroke.InterventionsNot applicable.Main outcome measuresPositive and negative predictive value and likelihood ratios of discharge destination for unfavorable outcome at 3- and 12-months poststroke defined by a Modified Rankin Scale (MRS) score of 2 to 6, 3 to 6, or 4 to 6. A likelihood ratio indicates how many times more (or less) likely a particular discharge destination is seen in patients with an unfavorable outcome compared with those without unfavorable outcome.ResultsThe positive predictive value of nursing home and rehabilitation facility discharges was highest for unfavorable outcome defined by an MRS score of 2 to 6 (95%) and rehabilitation facility (89%) at 3-months poststroke, respectively. The positive predictive value of rehabilitation facility/nursing home (90%) was also highest for unfavorable outcomes defined by an MRS score of 2 to 6 compared with those defined by MRS scores of 3 to 6 (79%) and 4 to 6 (57%). The positive likelihood ratio was highest for nursing home discharges (13; 95% confidence interval [CI], 4.1-41) followed by rehabilitation facility discharges for unfavorable outcome defined by an MRS score of 2 to 6 at 3-months poststroke (5.3; 95% CI, 3.5-7.9). The negative likelihood ratio was the highest for home discharge for unfavorable outcome defined by an MRS score of 2 to 6 (4.5; 95% CI, 3.4-6.1). A similar pattern was observed with unfavorable outcome defined using various thresholds at 12 months.ConclusionsDischarge destination can provide high predictive values and likelihood ratios for death and disability at 3-months poststroke, as defined by an MRS of score of 2 to 6.

Dataset Information

Validation of a German-language modified Rankin Scale structured telephone interview at 3 months in a real-life stroke cohort.

Background

Methods

Results

Conclusions

Publications

Validation of a German-language modified Rankin Scale structured telephone interview at 3 months in a real-life stroke cohort.

Similar Datasets

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