Ontology highlight
ABSTRACT:
SUBMITTER: Cazalla D
PROVIDER: S-EPMC1069619 | biostudies-literature | 2005 Apr
REPOSITORIES: biostudies-literature
Cazalla Demian D Newton Kathryn K Cáceres Javier F JF
Molecular and cellular biology 20050401 8
The SR family proteins and SR-related polypeptides are important regulators of pre-mRNA splicing. A novel SR-related protein of an apparent molecular mass of 53 kDa was isolated in a gene trap screen that identifies proteins which localize to the nuclear speckles. This novel protein possesses an arginine- and serine-rich domain and was termed SRrp53 (for SR-related protein of 53 kDa). In support for a role of this novel RS-containing protein in pre-mRNA splicing, we identified the mouse ortholog ...[more]