Ontology highlight
ABSTRACT:
SUBMITTER: Ta L
PROVIDER: S-EPMC10711388 | biostudies-literature | 2023 Dec
REPOSITORIES: biostudies-literature
Ta Lisa L Tsai Brandon L BL Deng Weixian W Sha Jihui J Varuzhanyan Grigor G Tran Wendy W Wohlschlegel James A JA Carr-Ascher Janai R JR Witte Owen N ON
iScience 20231117 12
Mutated Ras and Raf kinases are well-known to promote cancer metastasis via flux through the Ras/Raf/MEK/ERK (mitogen-activated protein kinase [MAPK]) pathway. A role for non-mutated Raf in metastasis is also emerging, but the key mechanisms remain unclear. Elevated expression of any of the three wild-type Raf family members (C, A, or B) can drive metastasis. We utilized an <i>in vivo</i> model to show that wild-type C-Raf overexpression can promote metastasis of immortalized prostate cells in a ...[more]