Ontology highlight
ABSTRACT:
SUBMITTER: Wang J
PROVIDER: S-EPMC3445712 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
Wang Jingqiang J Kobayashi Takashi T Floc'h Nicolas N Kinkade Carolyn Waugh CW Aytes Alvaro A Dankort David D Lefebvre Celine C Mitrofanova Antonina A Cardiff Robert D RD McMahon Martin M Califano Andrea A Shen Michael M MM Abate-Shen Cory C
Cancer research 20120725 18
Both the PI3K → Akt → mTOR and mitogen-activated protein kinase (MAPK) signaling pathways are often deregulated in prostate tumors with poor prognosis. Here we describe a new genetically engineered mouse model of prostate cancer in which PI3K-Akt-mTOR signaling is activated by inducible disruption of PTEN, and extracellular signal-regulated kinase 1/2 (ERK1/2) MAPK signaling is activated by inducible expression of a BRAF(V600E) oncogene. These tissue-specific compound mutant mice develop lethal ...[more]