Ontology highlight
ABSTRACT:
SUBMITTER: Cao Z
PROVIDER: S-EPMC10722604 | biostudies-literature | 2023 Nov
REPOSITORIES: biostudies-literature
Cao Zhengcong Z Liu Xiao X Zhang Wangqian W Zhang Keying K Pan Luxiang L Zhu Maorong M Qin Haozhe H Zou Cheng C Wang Weizhong W Zhang Cong C He Yalong Y Lin Wei W Zhang Yingqi Y Han Donghui D Li Meng M Gu Jintao J
ACS nano 20231122 23
The increasing understanding of ferroptosis has indicated its role and therapeutic potential in cancer; however, this knowledge has yet to be translated into effective therapies. Glioblastoma (GBM) patients face a bleak prognosis and encounter challenges due to the limited treatment options available. In this study, we conducted a genome-wide CRISPR-Cas9 screening in the presence of a ferroptosis inducer (RSL3) to identify the key driver genes involved in ferroptosis. We identified ALOX15, a key ...[more]