Ontology highlight
ABSTRACT:
SUBMITTER: Hu CM
PROVIDER: S-EPMC3131364 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Hu Che-Ming J CM Zhang Li L Aryal Santosh S Cheung Connie C Fang Ronnie H RH Zhang Liangfang L
Proceedings of the National Academy of Sciences of the United States of America 20110620 27
Efforts to extend nanoparticle residence time in vivo have inspired many strategies in particle surface modifications to bypass macrophage uptake and systemic clearance. Here we report a top-down biomimetic approach in particle functionalization by coating biodegradable polymeric nanoparticles with natural erythrocyte membranes, including both membrane lipids and associated membrane proteins for long-circulating cargo delivery. The structure, size and surface zeta potential, and protein contents ...[more]