Dataset Information

Association between non-cystic fibrosis bronchiectasis and the risk of incident dementia: A nationwide cohort study.

ABSTRACT:

Background

Chronic lung diseases, such as chronic obstructive pulmonary disease or asthma, are associated with an increased risk of dementia. However, few data are available regarding the risk of dementia in individuals with bronchiectasis.

Objectives

To explore the association between bronchiectasis and the risk of incident dementia using a longitudinal population-based cohort.

Methods

A total of 4,068,560 adults older than 50 years without previous dementia were enrolled from the Korean National Health Insurance Service database in 2009. They were followed up until the date of the diagnosis of dementia or December 31, 2020. The study exposure was the diagnosis of bronchiectasis, and the primary outcome was incident dementia comprising Alzheimer's disease and vascular dementia.

Results

During the median follow-up duration of 9.3 years, the incidence of all-cause dementia was 1.6-fold higher in individuals with bronchiectasis than in those without bronchiectasis (15.0 vs. 9.3/1000 person-years, p < .001). In the multivariable Cox regression analysis, the risk of all dementia was significantly higher in individuals with bronchiectasis than in those without bronchiectasis (adjusted hazard ratio [aHR] 1.09, 95% confidence interval [CI] 1.04-1.14). In a subgroup analysis by dementia type, individuals with bronchiectasis had an increased risk of Alzheimer's disease compared to those without bronchiectasis (aHR 1.07, 95% CI 1.01-1.12); the risk of vascular dementia did not significantly differ between the two groups (aHR 1.05, 95% CI 0.90-1.21).

Conclusion

Bronchiectasis was associated with an increased risk of dementia, especially Alzheimer's disease.

SUBMITTER: Kim SH

PROVIDER: S-EPMC10725102 | biostudies-literature | 2023 Jan-Dec

REPOSITORIES: biostudies-literature

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Publications

Association between non-cystic fibrosis bronchiectasis and the risk of incident dementia: A nationwide cohort study.

Kim Sang Hyuk SH Han Kyungdo K Park Jongkyu J Park Dong Won DW Moon Ji-Yong JY Sim Yun Su YS Kim Tae-Hyung TH Kim Sang-Heon SH Sohn Jang Won JW Yoon Ho Joo HJ Lee Hyun H Choi Hayoung H

Chronic respiratory disease 20230101

<h4>Background</h4>Chronic lung diseases, such as chronic obstructive pulmonary disease or asthma, are associated with an increased risk of dementia. However, few data are available regarding the risk of dementia in individuals with bronchiectasis.<h4>Objectives</h4>To explore the association between bronchiectasis and the risk of incident dementia using a longitudinal population-based cohort.<h4>Methods</h4>A total of 4,068,560 adults older than 50 years without previous dementia were enrolled ...[more]

PMID: 38100725

Similar Datasets

Project description:Rationale: Non-cystic fibrosis bronchiectasis is characterized by airway mucus accumulation and sputum production, but the role of mucus concentration in the pathogenesis of these abnormalities has not been characterized.Objectives: This study was designed to: 1) measure mucus concentration and biophysical properties of bronchiectasis mucus; 2) identify the secreted mucins contained in bronchiectasis mucus; 3) relate mucus properties to airway epithelial mucin RNA/protein expression; and 4) explore relationships between mucus hyperconcentration and disease severity.Methods: Sputum samples were collected from subjects with bronchiectasis, with and without chronic erythromycin administration, and healthy control subjects. Sputum percent solid concentrations, total and individual mucin concentrations, osmotic pressures, rheological properties, and inflammatory mediators were measured. Intracellular mucins were measured in endobronchial biopsies by immunohistochemistry and gene expression. MUC5B (mucin 5B) polymorphisms were identified by quantitative PCR. In a replication bronchiectasis cohort, spontaneously expectorated and hypertonic saline-induced sputa were collected, and mucus/mucin concentrations were measured.Measurements and Main Results: Bronchiectasis sputum exhibited increased percent solids, total and individual (MUC5B and MUC5AC) mucin concentrations, osmotic pressure, and elastic and viscous moduli compared with healthy sputum. Within subjects with bronchiectasis, sputum percent solids correlated inversely with FEV1 and positively with bronchiectasis extent, as measured by high-resolution computed tomography, and inflammatory mediators. No difference was detected in MUC5B rs35705950 SNP allele frequency between bronchiectasis and healthy individuals. Hypertonic saline inhalation acutely reduced non-cystic fibrosis bronchiectasis mucus concentration by 5%.Conclusions: Hyperconcentrated airway mucus is characteristic of subjects with bronchiectasis, likely contributes to disease pathophysiology, and may be a target for pharmacotherapy.

Dataset Information

Association between non-cystic fibrosis bronchiectasis and the risk of incident dementia: A nationwide cohort study.

Background

Objectives

Methods

Results

Conclusion

Publications

Association between non-cystic fibrosis bronchiectasis and the risk of incident dementia: A nationwide cohort study.

Similar Datasets

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