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ABSTRACT: Background
We assessed the relationship of liver fibrosis score with incident dementia in a large, national sample.Methods
For this retrospective cohort study, data of dementia-free individuals aged 40-69 years were derived from electronic records of the largest healthcare provider in Israel. The association between liver fibrosis score (FIB-4), assessed from routine laboratory measurements, and incident dementia was explored through multivariate cox regression models.Results
Of the total sample (N = 826,578, mean age 55 ± 8 years at baseline), 636,967 (77%) had no fibrosis, 180,114 (21.8%) had inconclusive fibrosis status and 9497 (1.2%) had high risk for advanced fibrosis. Over a median follow-up of 17 years, 41,089 dementia cases were recorded. Inconclusive liver fibrosis and advanced fibrosis were associated with increased dementia risk (HR = 1.09, 95%CI: 1.07-1.11 and HR = 1.18, 95%CI: 1.10-1.27, respectively). This association remained robust through seven sensitivity analyses.Conclusions
Liver fibrosis assessed through a serum-based algorithm may serve as a risk factor for dementia in the general population.Highlights
Liver fibrosis may predict dementia diagnosis in the general population. Inconclusive liver fibrosis was associated with 9% increased dementia risk. Advanced liver fibrosis was associated with 18% increased dementia risk. Findings remained robust in sensitivity analyses and after adjustments.
SUBMITTER: Weinstein G
PROVIDER: S-EPMC11350139 | biostudies-literature | 2024 Aug
REPOSITORIES: biostudies-literature
Weinstein Galit G Schonmann Yochai Y Yeshua Hanny H Zelber-Sagi Shira S
Alzheimer's & dementia : the journal of the Alzheimer's Association 20240701 8
<h4>Background</h4>We assessed the relationship of liver fibrosis score with incident dementia in a large, national sample.<h4>Methods</h4>For this retrospective cohort study, data of dementia-free individuals aged 40-69 years were derived from electronic records of the largest healthcare provider in Israel. The association between liver fibrosis score (FIB-4), assessed from routine laboratory measurements, and incident dementia was explored through multivariate cox regression models.<h4>Results ...[more]