Dataset Information

Preoperative assessment of retroperitoneal Liposarcoma using volume-based ¹⁸F-FDG PET/CT: implications for surgical strategy and prognosis.

ABSTRACT:

Purpose

Retroperitoneal liposarcoma (RLPS) poses a challenging scenario for surgeons due to its unpredictable biological behavior. Surgery remains the primary curative option for RLPS; however, the need for additional information to guide surgical strategies persists. Volume-based ¹⁸F-FDG PET/CT may solve this issue.

Methods

We analyzed data from 89 RLPS patients, measuring metabolic tumor volume (MTV), total lesion glycolysis (TLG), and maximum standardized uptake value (SUVmax) and explored their associations with clinical, prognostic, and pathological factors.

Results

MTV, TLG of multifocal and recurrent RLPS were significantly higher than unifocal and primary ones (P < 0.001, P < 0.001, P = 0.003 and P = 0.002, respectively). SUVmax correlated with FNCLCC histological grade, mitotic count and Ki-67 index (P for G1/G2 = 0.005, P for G2/G3 = 0.017, and P for G1/G3 = 0.001, P < 0.001 and P = 0.024, respectively). MTG, TLG and SUVmax of WDLPS were significantly lower than DDLPS and PLPS (P for MTV were 0.009 and 0.022, P for TLG were 0.028 and 0.048, and P for SUVmax were 0.027 and < 0.001, respectively). Multivariable Cox analysis showed that MTV > 457.65 (P = 0.025), pathological subtype (P = 0.049) and FNCLCC histological grade (P = 0.033) were related to overall survival (OS).

Conclusions

Our findings indicate that MTV is an independent prognostic factor for RLPS, while MTV, TLG, and SUVmax can preoperatively predict multifocal lesions, histological grade, and pathological subtype. Volume-based ¹⁸F-FDG PET/CT offers valuable information to aid in the decision-making process for RLPS surgical strategies.

SUBMITTER: Liu DN

PROVIDER: S-EPMC10726537 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature

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Publications

Preoperative assessment of retroperitoneal Liposarcoma using volume-based <sup>18</sup>F-FDG PET/CT: implications for surgical strategy and prognosis.

Liu Dao-Ning DN Wu Jian-Hui JH Li Zhong-Wu ZW Wang Hai-Yue HY Tian Xiu-Yun XY Hao Chun-Yi CY

BMC medical imaging 20231218 1

<h4>Purpose</h4>Retroperitoneal liposarcoma (RLPS) poses a challenging scenario for surgeons due to its unpredictable biological behavior. Surgery remains the primary curative option for RLPS; however, the need for additional information to guide surgical strategies persists. Volume-based <sup>18</sup>F-FDG PET/CT may solve this issue.<h4>Methods</h4>We analyzed data from 89 RLPS patients, measuring metabolic tumor volume (MTV), total lesion glycolysis (TLG), and maximum standardized uptake valu ...[more]

PMID: 38110909

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Dataset Information

Preoperative assessment of retroperitoneal Liposarcoma using volume-based ¹⁸F-FDG PET/CT: implications for surgical strategy and prognosis.

Purpose

Methods

Results

Conclusions

Publications

Preoperative assessment of retroperitoneal Liposarcoma using volume-based <sup>18</sup>F-FDG PET/CT: implications for surgical strategy and prognosis.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Dataset Information

Preoperative assessment of retroperitoneal Liposarcoma using volume-based 18F-FDG PET/CT: implications for surgical strategy and prognosis.

Purpose

Methods

Results

Conclusions

Publications

Preoperative assessment of retroperitoneal Liposarcoma using volume-based <sup>18</sup>F-FDG PET/CT: implications for surgical strategy and prognosis.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Preoperative assessment of retroperitoneal Liposarcoma using volume-based ¹⁸F-FDG PET/CT: implications for surgical strategy and prognosis.