Ontology highlight
ABSTRACT:
SUBMITTER: Moller AF
PROVIDER: S-EPMC10733431 | biostudies-literature | 2023 Dec
REPOSITORIES: biostudies-literature
Møller Andreas Fønss AF Madsen Jesper Grud Skat JGS
Nature communications 20231220 1
Single-cell and single-nucleus RNA-sequencing (sxRNA-seq) is increasingly being used to characterise the transcriptomic state of cell types at homeostasis, during development and in disease. However, this is a challenging task, as biological effects can be masked by technical variation. Here, we present JOINTLY, an algorithm enabling joint clustering of sxRNA-seq datasets across batches. JOINTLY performs on par or better than state-of-the-art batch integration methods in clustering tasks and out ...[more]