Dataset Information

Investigating the Relationship Between Smoking Behavior and Global Brain Volume.

ABSTRACT:

Background

Previous studies have shown that brain volume is negatively associated with cigarette smoking, but there is an ongoing debate about whether smoking causes lowered brain volume or a lower brain volume is a risk factor for smoking. We address this debate through multiple methods that evaluate directionality: Bradford Hill's criteria, which are commonly used to understand a causal relationship in epidemiological studies, and mediation analysis.

Methods

In 32,094 participants of European descent from the UK Biobank dataset, we examined the relationship between a history of daily smoking and brain volumes, as well as an association of genetic risk score to ever smoking with brain volume.

Results

A history of daily smoking was strongly associated with decreased brain volume, and a history of heavier smoking was associated with a greater decrease in brain volume. The strongest association was between total gray matter volume and a history of daily smoking (effect size = -2964 mm³, p = 2.04 × 10^-16), and there was a dose-response relationship with more pack years smoked associated with a greater decrease in brain volume. A polygenic risk score for smoking initiation was strongly associated with a history of daily smoking (effect size = 0.05, p = 4.20 × 10^-84), but only modestly associated with total gray matter volume (effect size = -424 mm³, p = .01). Mediation analysis indicated that a history of daily smoking mediated the relationship between the smoking initiation polygenic risk score and total gray matter volume.

Conclusions

A history of daily smoking is strongly associated with a decreased total brain volume.

SUBMITTER: Chang Y

PROVIDER: S-EPMC10733671 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature

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Publications

Investigating the Relationship Between Smoking Behavior and Global Brain Volume.

Chang Yoonhoo Y Thornton Vera V Chaloemtoem Ariya A Anokhin Andrey P AP Bijsterbosch Janine J Bogdan Ryan R Hancock Dana B DB Johnson Eric Otto EO Bierut Laura J LJ

Biological psychiatry global open science 20231006 1

<h4>Background</h4>Previous studies have shown that brain volume is negatively associated with cigarette smoking, but there is an ongoing debate about whether smoking causes lowered brain volume or a lower brain volume is a risk factor for smoking. We address this debate through multiple methods that evaluate directionality: Bradford Hill's criteria, which are commonly used to understand a causal relationship in epidemiological studies, and mediation analysis.<h4>Methods</h4>In 32,094 participan ...[more]

PMID: 38130847

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Dataset Information

Investigating the Relationship Between Smoking Behavior and Global Brain Volume.

Background

Methods

Results

Conclusions

Publications

Investigating the Relationship Between Smoking Behavior and Global Brain Volume.

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