Ontology highlight
ABSTRACT:
SUBMITTER: Filippi L
PROVIDER: S-EPMC10741994 | biostudies-literature | 2023 Dec
REPOSITORIES: biostudies-literature
Filippi Luca L Nardini Patrizia P Zizi Virginia V Molino Marta M Fazi Camilla C Calvani Maura M Carrozzo Francesco F Cavallaro Giacomo G Giuseppetti Giorgia G Calosi Laura L Crociani Olivia O Pini Alessandro A
Biomolecules 20231206 12
Oxygen level is a key regulator of organogenesis and its modification in postnatal life alters the maturation process of organs, including the intestine, which do not completely develop in utero. The β3-adrenoreceptor (β3-AR) is expressed in the colon and has an oxygen-dependent regulatory mechanism. This study shows the effects of the β3-AR agonist BRL37344 in a neonatal model of hyperoxia-driven colonic injury. For the first 14 days after birth, Sprague-Dawley rat pups were exposed to ambient ...[more]