Dataset Information

Differentiating Cardiac Troponin Levels During Cardiac Myosin Inhibition or Cardiac Myosin Activation Treatments: Drug Effect or the Canary in the Coal Mine?

ABSTRACT:

Purpose of review

Cardiac myosin inhibitors (CMIs) and activators are emerging therapies for hypertrophic cardiomyopathy (HCM) and heart failure with reduced ejection fraction (HFrEF), respectively. However, their effects on cardiac troponin levels, a biomarker of myocardial injury, are incompletely understood.

Recent findings

In patients with HCM, CMIs cause substantial reductions in cardiac troponin levels which are reversible after stopping treatment. In patients with HFrEF, cardiac myosin activator (omecamtiv mecarbil) therapy cause modest increases in cardiac troponin levels which are reversible following treatment cessation and not associated with myocardial ischaemia or infarction. Transient changes in cardiac troponin levels might reflect alterations in cardiac contractility and mechanical stress. Such transient changes might not indicate cardiac injury and do not appear to be associated with adverse outcomes in the short to intermediate term. Longitudinal changes in troponin levels vary depending on the population and treatment. Further research is needed to elucidate mechanisms underlying changes in troponin levels.

SUBMITTER: Lee MMY

PROVIDER: S-EPMC10746589 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature

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Publications

Differentiating Cardiac Troponin Levels During Cardiac Myosin Inhibition or Cardiac Myosin Activation Treatments: Drug Effect or the Canary in the Coal Mine?

Lee Matthew M Y MMY Masri Ahmad A

Current heart failure reports 20231025 6

<h4>Purpose of review</h4>Cardiac myosin inhibitors (CMIs) and activators are emerging therapies for hypertrophic cardiomyopathy (HCM) and heart failure with reduced ejection fraction (HFrEF), respectively. However, their effects on cardiac troponin levels, a biomarker of myocardial injury, are incompletely understood.<h4>Recent findings</h4>In patients with HCM, CMIs cause substantial reductions in cardiac troponin levels which are reversible after stopping treatment. In patients with HFrEF, ca ...[more]

PMID: 37875744

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Project description:IntroductionDespite increasing evidence that Environmental Health Monitoring (EHM) is an effective method to perform rodent colony health surveillance, promotes the 3Rs as a Replacement, is comparable or reduces cost, and demonstrates labor benefits, many research institutions continue to use live Soiled Bedding Sentinels (SBS). Some veterinarians and others responsible for rodent colony health monitoring remain cautious of the evidence supporting this new technology. Therefore, our objective was to perform a formal systematic review to identify, summarize, and evaluate the research on the efficacy of EHM as compared to SBS. This information is essential to establishing recommendations for rodent health monitoring programs.MethodsWe systematically searched and evaluated all articles comparing EHM to SBS identified from PubMed, Web of Science, and CAB abstracts initially on November 12, 2021 with an update on Oct 15, 2023. Our inclusion criteria included publication in a peer-reviewed journal and collection of empirical data on rodent health monitoring alternatives to soiled bedding sentinels. Outcome data was extracted and analyzed via logistic regression and secondary descriptive statistics. Due to the nature of the included studies, no risk of bias assessment was performed. No specific funding was received for this review.ResultsForty-two peer-reviewed articles passed inclusion criteria for analysis. The design of studies varied substantially but included publications investigating exhaust dust testing (n = 27), sentinel-free soiled bedding (n = 8), and direct colony sampling (n = 24). Based on both logistical regression and descriptive criteria, all types of EHM appear to be superior to soiled bedding sentinels at detecting pathogens, regardless of their taxonomic classification.ConclusionBased on these findings, we conclude there is a strong evidence base supporting the replacement of SBS with EHM. Looking forward, we encourage continued research on the detection of existing and emerging pathogens with these technologies and development of best practices for routine rodent health monitoring programs.

Dataset Information

Differentiating Cardiac Troponin Levels During Cardiac Myosin Inhibition or Cardiac Myosin Activation Treatments: Drug Effect or the Canary in the Coal Mine?

Purpose of review

Recent findings

Publications

Differentiating Cardiac Troponin Levels During Cardiac Myosin Inhibition or Cardiac Myosin Activation Treatments: Drug Effect or the Canary in the Coal Mine?

Similar Datasets

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