Dataset Information

Effect of preterm birth on growth and blood pressure in adulthood in the Pelotas 1993 cohort.

ABSTRACT:

Background

Preterm birth has been associated with increased risk of hypertension and cardiovascular disease later in adulthood, attributed to cardiovascular and metabolic alterations in early life. However, there is paucity of evidence from low- and middle-income countries (LMICs).

Methods

We investigated the differences between preterm (<37 weeks gestational age) and term-born individuals in birth length and weight as well as adult (18 and 20 years) height, weight and blood pressure in the Brazilian 1993 Pelotas birth cohort using linear regressions. Analyses were adjusted for the maternal weight at the beginning of pregnancy and maternal education and family income at childbirth. Additional models were adjusted for body mass index (BMI) and birthweight. Separate analyses were run for males and females. The complete sample was analysed with an interaction term for sex.

Results

Of the 3585 babies included at birth, 3010 were followed up in adulthood at 22 years. Preterm participants had lower length and weight at birth. This difference remained for male participants in adulthood, but female participants were no shorter than their term counterparts by 18 years of age. At 22 years, females born preterm had lower blood pressures (systolic blood pressure -1.00 mmHg, 95%CI -2.7, 0.7 mmHg; diastolic blood pressure -1.1 mmHg, 95%CI -2.4, 0.3 mmHg) than females born at term. These differences were not found in male participants.

Conclusions

In this Brazilian cohort we found contrasting results regarding the association of preterm birth with blood pressure in young adulthood, which may be unique to an LMIC.

SUBMITTER: Lapidaire W

PROVIDER: S-EPMC10749774 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature

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Publications

Effect of preterm birth on growth and blood pressure in adulthood in the Pelotas 1993 cohort.

Lapidaire Winok W Proaño Alvaro A Blumenberg Cauane C Loret de Mola Christian C Delgado Carlos A CA Del Castillo Darwin D Wehrmeister Fernando C FC Gonçalves Helen H Gilman Robert H RH Oberhelman Richard A RA Lewandowski Adam J AJ Wells Jonathan C K JCK Miranda J Jaime JJ

International journal of epidemiology 20231201 6

<h4>Background</h4>Preterm birth has been associated with increased risk of hypertension and cardiovascular disease later in adulthood, attributed to cardiovascular and metabolic alterations in early life. However, there is paucity of evidence from low- and middle-income countries (LMICs).<h4>Methods</h4>We investigated the differences between preterm (<37 weeks gestational age) and term-born individuals in birth length and weight as well as adult (18 and 20 years) height, weight and blood press ...[more]

PMID: 37354551

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Project description:BACKGROUND:Evidence regarding the deleterious effects of diet on blood lipids in adolescence has been inconsistent, and few studies have investigated this association using a dietary pattern approach. We examined whether dietary pattern of adolescents are associated with blood lipid concentrations. METHODS:Cross-sectional analysis of 3524 18-year-old participants in the 1993 Pelotas (Brazil) Birth Cohort Study. A semi-quantitative food frequency questionnaire was administered. Dietary patterns were established using principal component analysis and analysed as tertiles of factor scores. Independent associations between each dietary pattern tertile and blood lipid values (total cholesterol, LDL-cholesterol, HDL-cholesterol and triglycerides) were tested using adjusted linear regression models stratified by sex. Triglycerides were log-transformed due to their skewed distribution, and the beta coefficients should be interpreted as the % change (increase or decrease). RESULTS:Four dietary patterns were derived: Meat Products and Fast Foods; Fruits and Vegetables; Candies, Sodas and Dairy Products; and Common Brazilian Foods. In the adjusted models, which compared the highest and lowest tertiles of dietary pattern scores, we observed that among girls: 1) the third tertile of the Meat Products and Fast Foods pattern was associated with 1.5 mg/dL (95% CI -3.05; -0.04) lower HDL-cholesterol; 2) the second and third tertile of the Candies, Sodas and Dairy Products pattern was associated with 5% and 10% higher triglycerides (β 1.05, 95% CI 1.01; 1.09, β 1.10, 95% CI 1.05; 1.16), respectively; 3) the second and third tertiles of the Common Brazilian Foods pattern were associated with 4 mg/dL (β - 4.30, 95% CI -7.75; -0.85, β - 4.95, 95% CI -8.53; -1.36, respectively) lower total cholesterol and 6% lower triglycerides (β 0.94, 95% CI 0.90; 0.99, β 0.93, 95% CI 0.89; 0.98, respectively). For boys, 4) the third tertile of the Common Brazilian Foods was associated with 4.6 mg/dL (95% CI -7.91; -1.37) lower total cholesterol and 3.8 mg/dL (95% CI -6.51; - 1.13) lower LDL-cholesterol. CONCLUSIONS:Dietary patterns were more closely associated with blood lipids among girls than boys at age 18. Higher scores for the Common Brazilian Foods pattern were associated with lower total cholesterol in both sexes.

Dataset Information

Effect of preterm birth on growth and blood pressure in adulthood in the Pelotas 1993 cohort.

Background

Methods

Results

Conclusions

Publications

Effect of preterm birth on growth and blood pressure in adulthood in the Pelotas 1993 cohort.

Similar Datasets

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