Ontology highlight
ABSTRACT:
SUBMITTER: Ashbaugh CD
PROVIDER: S-EPMC107524 | biostudies-literature | 1998 Sep
REPOSITORIES: biostudies-literature
Ashbaugh C D CD Albertí S S Wessels M R MR
Journal of bacteriology 19980901 18
Enzymes directing the biosynthesis of the group A streptococcal hyaluronic acid capsule are encoded in the hasABC gene cluster. Inactivation of hasC, encoding UDP-glucose pyrophosphorylase in the heavily encapsulated group A streptococcal strain 87-282, had no effect on capsule production, indicating that hasC is not required for hyaluronic acid synthesis and that an alternative source of UDP-glucose is available for capsule production. Nucleotide sequence and deletion mutation analysis of the 5 ...[more]