Ontology highlight
ABSTRACT:
SUBMITTER: Yang S
PROVIDER: S-EPMC10766616 | biostudies-literature | 2024 Jan
REPOSITORIES: biostudies-literature
Yang Shan S Chen Ruibing R Cao Xuan X Wang Guodong G Zhou Yongjin J YJ
Nature communications 20240104 1
The flavonoid xanthohumol is an important flavor substance in the brewing industry that has a wide variety of bioactivities. However, its unstable structure results in its low content in beer. Microbial biosynthesis is considered a sustainable and economically viable alternative. Here, we harness the yeast Saccharomyces cerevisiae for the de novo biosynthesis of xanthohumol from glucose by balancing the three parallel biosynthetic pathways, prenyltransferase engineering, enhancing precursor supp ...[more]