Ontology highlight
ABSTRACT:
SUBMITTER: Hermansen RA
PROVIDER: S-EPMC4625875 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Hermansen Russell A RA Mannakee Brian K BK Knecht Wolfgang W Liberles David A DA Gutenkunst Ryan N RN
BMC evolutionary biology 20151028
<h4>Background</h4>Selection on proteins is typically measured with the assumption that each protein acts independently. However, selection more likely acts at higher levels of biological organization, requiring an integrative view of protein function. Here, we built a kinetic model for de novo pyrimidine biosynthesis in the yeast Saccharomyces cerevisiae to relate pathway function to selective pressures on individual protein-encoding genes.<h4>Results</h4>Gene families across yeast were constru ...[more]