Genome-wide association study meta-analysis of dizygotic twinning illuminates genetic regulation of female fecundity.
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ABSTRACT:
SUBMITTER: Mbarek H
PROVIDER: S-EPMC10767824 | biostudies-literature | 2024 Jan
REPOSITORIES: biostudies-literature
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Genome-wide association study meta-analysis of dizygotic twinning illuminates genetic regulation of female fecundity.
Mbarek Hamdi H Gordon Scott D SD Duffy David L DL Hubers Nikki N Mortlock Sally S Beck Jeffrey J JJ Hottenga Jouke-Jan JJ Pool René R Dolan Conor V CV Actkins Ky'Era V KV Gerring Zachary F ZF Van Dongen Jenny J Ehli Erik A EA Iacono William G WG Mcgue Matt M Chasman Daniel I DI Gallagher C Scott CS Schilit Samantha L P SLP Morton Cynthia C CC Paré Guillaume G Willemsen Gonneke G Whiteman David C DC Olsen Catherine M CM Derom Catherine C Vlietinck Robert R Gudbjartsson Daniel D Cannon-Albright Lisa L Krapohl Eva E Plomin Robert R Magnusson Patrik K E PKE Pedersen Nancy L NL Hysi Pirro P Mangino Massimo M Spector Timothy D TD Palviainen Teemu T Milaneschi Yuri Y Penninnx Brenda W BW Campos Adrian I AI Ong Ken K KK Perry John R B JRB Lambalk Cornelis B CB Kaprio Jaakko J Ólafsson Ísleifur Í Duroure Karine K Revenu Céline C Rentería Miguel E ME Yengo Loic L Davis Lea L Derks Eske M EM Medland Sarah E SE Stefansson Hreinn H Stefansson Kari K Del Bene Filippo F Reversade Bruno B Montgomery Grant W GW Boomsma Dorret I DI Martin Nicholas G NG
Human reproduction (Oxford, England) 20240101 1
<h4>Study question</h4>Which genetic factors regulate female propensity for giving birth to spontaneous dizygotic (DZ) twins?<h4>Summary answer</h4>We identified four new loci, GNRH1, FSHR, ZFPM1, and IPO8, in addition to previously identified loci, FSHB and SMAD3.<h4>What is known already</h4>The propensity to give birth to DZ twins runs in families. Earlier, we reported that FSHB and SMAD3 as associated with DZ twinning and female fertility measures.<h4>Study design, size, duration</h4>We cond ...[more]
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