Dataset Information

Dissecting components of the Campylobacter jejuni fetMP-fetABCDEF gene cluster under iron limitation.

ABSTRACT:

Importance

Campylobacter jejuni is a bacterium that is prevalent in the ceca of farmed poultry such as chickens. Consumption of ill-prepared poultry is thus the most common route by which C. jejuni infects the human gut to cause a typically self-limiting but severe gastrointestinal illness that can be fatal to very young, old, or immunocompromised people. The lack of a vaccine and an increasing resistance to current antibiotics highlight a need to better understand the mechanisms that make C. jejuni a successful human pathogen. This study focused on the functional components of one such mechanism-a molecular system that helps C. jejuni thrive despite the restriction on growth-available iron by the human body, which typically defends against pathogens. In providing a deeper understanding of how this system functions, this study contributes toward the goal of reducing the enormous global socioeconomic burden caused by C. jejuni.

SUBMITTER: Richardson-Sanchez T

PROVIDER: S-EPMC10783030 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature

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Dissecting components of the <i>Campylobacter jejuni fetMP-fetABCDEF</i> gene cluster under iron limitation.

Richardson-Sanchez Tomas T Chan Anson C K ACK Sabatino Brendil B Lin Helen H Gaynor Erin C EC Murphy Michael E P MEP

Microbiology spectrum 20231214 1

<h4>Importance</h4><i>Campylobacter jejuni</i> is a bacterium that is prevalent in the ceca of farmed poultry such as chickens. Consumption of ill-prepared poultry is thus the most common route by which <i>C. jejuni</i> infects the human gut to cause a typically self-limiting but severe gastrointestinal illness that can be fatal to very young, old, or immunocompromised people. The lack of a vaccine and an increasing resistance to current antibiotics highlight a need to better understand the mech ...[more]

PMID: 38096459

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