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Toxin/antitoxin systems induce persistence and work in concert with restriction/modification systems to inhibit phage.

ABSTRACT:

Importance

To date, there are no reports of phage infection-inducing persistence. Therefore, our results are important since we show for the first time that a phage-defense system, the MqsRAC toxin/antitoxin system, allows the host to survive infection by forming persister cells, rather than inducing cell suicide. Moreover, we demonstrate that the MqsRAC system works in concert with restriction/modification systems. These results imply that if phage therapy is to be successful, anti-persister compounds need to be administered along with phages.

SUBMITTER: Fernandez-Garcia L

PROVIDER: S-EPMC10783111 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature

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Toxin/antitoxin systems induce persistence and work in concert with restriction/modification systems to inhibit phage.

Fernández-García Laura L Song Sooyeon S Kirigo Joy J Battisti Michael E ME Petersen Maiken E ME Tomás María M Wood Thomas K TK

Microbiology spectrum 20231206 1

<h4>Importance</h4>To date, there are no reports of phage infection-inducing persistence. Therefore, our results are important since we show for the first time that a phage-defense system, the MqsRAC toxin/antitoxin system, allows the host to survive infection by forming persister cells, rather than inducing cell suicide. Moreover, we demonstrate that the MqsRAC system works in concert with restriction/modification systems. These results imply that if phage therapy is to be successful, anti-pers ...[more]

PMID: 38054715

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