Protein target highlights in CASP15: Analysis of models by structure providers.
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ABSTRACT:
SUBMITTER: Alexander LT
PROVIDER: S-EPMC10792529 | biostudies-literature | 2023 Dec
REPOSITORIES: biostudies-literature
Publications
Protein target highlights in CASP15: Analysis of models by structure providers.
Alexander Leila T LT Durairaj Janani J Kryshtafovych Andriy A Abriata Luciano A LA Bayo Yusupha Y Bhabha Gira G Breyton Cécile C Caulton Simon G SG Chen James J Degroux Séraphine S Ekiert Damian C DC Erlandsen Benedikte S BS Freddolino Lydia L Gilzer Dominic D Greening Chris C Grimes Jonathan M JM Grinter Rhys R Gurusaran Manickam M Hartmann Marcus D MD Hitchman Charlie J CJ Keown Jeremy R JR Kropp Ashleigh A Kursula Petri P Lovering Andrew L AL Lemaitre Bruno B Lia Andrea A Liu Shiheng S Logotheti Maria M Lu Shuze S Markússon Sigurbjörn S Miller Mitchell D MD Minasov George G Niemann Hartmut H HH Opazo Felipe F Phillips George N GN Davies Owen R OR Rommelaere Samuel S Rosas-Lemus Monica M Roversi Pietro P Satchell Karla K Smith Nathan N Wilson Mark A MA Wu Kuan-Lin KL Xia Xian X Xiao Han H Zhang Wenhua W Zhou Z Hong ZH Fidelis Krzysztof K Topf Maya M Moult John J Schwede Torsten T
Proteins 20230726 12
We present an in-depth analysis of selected CASP15 targets, focusing on their biological and functional significance. The authors of the structures identify and discuss key protein features and evaluate how effectively these aspects were captured in the submitted predictions. While the overall ability to predict three-dimensional protein structures continues to impress, reproducing uncommon features not previously observed in experimental structures is still a challenge. Furthermore, instances w ...[more]
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