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Target highlights in CASP14: Analysis of models by structure providers.


ABSTRACT: The biological and functional significance of selected Critical Assessment of Techniques for Protein Structure Prediction 14 (CASP14) targets are described by the authors of the structures. The authors highlight the most relevant features of the target proteins and discuss how well these features were reproduced in the respective submitted predictions. The overall ability to predict three-dimensional structures of proteins has improved remarkably in CASP14, and many difficult targets were modeled with impressive accuracy. For the first time in the history of CASP, the experimentalists not only highlighted that computational models can accurately reproduce the most critical structural features observed in their targets, but also envisaged that models could serve as a guidance for further studies of biologically-relevant properties of proteins.

SUBMITTER: Alexander LT 

PROVIDER: S-EPMC8616854 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature

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Target highlights in CASP14: Analysis of models by structure providers.

Alexander Leila T LT   Lepore Rosalba R   Kryshtafovych Andriy A   Adamopoulos Athanassios A   Alahuhta Markus M   Arvin Ann M AM   Bomble Yannick J YJ   Böttcher Bettina B   Breyton Cécile C   Chiarini Valerio V   Chinnam Naga Babu NB   Chiu Wah W   Fidelis Krzysztof K   Grinter Rhys R   Gupta Gagan D GD   Hartmann Marcus D MD   Hayes Christopher S CS   Heidebrecht Tatjana T   Ilari Andrea A   Joachimiak Andrzej A   Kim Youngchang Y   Linares Romain R   Lovering Andrew L AL   Lunin Vladimir V VV   Lupas Andrei N AN   Makbul Cihan C   Michalska Karolina K   Moult John J   Mukherjee Prasun K PK   Nutt William Sam WS   Oliver Stefan L SL   Perrakis Anastassis A   Stols Lucy L   Tainer John A JA   Topf Maya M   Tsutakawa Susan E SE   Valdivia-Delgado Mauricio M   Schwede Torsten T  

Proteins 20211010 12


The biological and functional significance of selected Critical Assessment of Techniques for Protein Structure Prediction 14 (CASP14) targets are described by the authors of the structures. The authors highlight the most relevant features of the target proteins and discuss how well these features were reproduced in the respective submitted predictions. The overall ability to predict three-dimensional structures of proteins has improved remarkably in CASP14, and many difficult targets were modele  ...[more]

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