Local fractal dimension of collagen detects increased spatial complexity in fibrosis.
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ABSTRACT:
SUBMITTER: Casey DT
PROVIDER: S-EPMC10794291 | biostudies-literature | 2024 Jan
REPOSITORIES: biostudies-literature
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Local fractal dimension of collagen detects increased spatial complexity in fibrosis.
Casey Dylan T DT Lahue Karolyn G KG Mori Vitor V Herrmann Jacob J Hall Joseph K JK Suki Béla B Janssen-Heininger Yvonne M W YMW Bates Jason H T JHT
Histochemistry and cell biology 20231108 1
Increase of collagen content and reorganization characterizes fibrosis but quantifying the latter remains challenging. Spatially complex structures are often analyzed via the fractal dimension; however, established methods for calculating this quantity either provide a single dimension for an entire object or a spatially distributed dimension that only considers binary images. These neglect valuable information related to collagen density in images of fibrotic tissue. We sought to develop a frac ...[more]
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