Dataset Information

Genetically divergent Francisella philomiragia associated with septic arthritis, Montevideo, Uruguay.

ABSTRACT: Here we report a case of septic arthritis associated with a genetically divergent Francisella philomiragia strain in a patient with chronic rheumatoid arthritis and Adult-onset Still's disease (AOSD) in Maldonado, Uruguay. In this study mass spectrometry together with whole-genome sequencing using Oxford Nanopore technology allowed for the correct identification of the etiologic agent.

SUBMITTER: Riera N

PROVIDER: S-EPMC10797181 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature

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Genetically divergent <i>Francisella philomiragia</i> associated with septic arthritis, Montevideo, Uruguay.

Riera Nadia N Salazar Cecilia C Rivera Bernardina B Galiana Antonio A Durán Rosario R Portela María Magdalena MM Antelo Virginia V Pi Beatriz B González Óscar Ó Iraola Gregorio G

New microbes and new infections 20231214

Here we report a case of septic arthritis associated with a genetically divergent <i>Francisella philomiragia</i> strain in a patient with chronic rheumatoid arthritis and Adult-onset Still's disease (AOSD) in Maldonado, Uruguay. In this study mass spectrometry together with whole-genome sequencing using Oxford Nanopore technology allowed for the correct identification of the etiologic agent. ...[more]

PMID: 38261949

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Project description:BackgroundNeighborhood disadvantage (ND) is a risk factor for child behavior problems (CBPs), but is understudied outside the United States and Europe. Our mixed methods study aims to (1) create a culturally meaningful measure of ND, (2) test cross-sectional associations between ND and CBPs and (3) qualitatively explore life in the neighborhoods of families participating in the Salud Ambiental Montevideo (SAM) study.MethodsThe quantitative study (Study 1) comprised 272, ~7-year-old children with geolocation and complete data on twelve behavioral outcomes (Conner's Teachers Rating Scale - Revised Short Form: CTRS-R:S and Behavioral Rating Inventory of Executive Functioning: BRIEF). A ND factor was created at the census segment level (1,055 segments) with 19 potential indicators of ND downloaded from the Municipality of Montevideo Geographic Services. Children were assigned ND scores based on the location of their household within a census segment. Multilevel models tested associations between ND and all CBP scales, controlling for confounders at the individual level. The qualitative study (Study 2) comprised 10 SAM caregivers. Photovoice alongside semi-structured interviews in Spanish were used to foster conversations about neighborhood quality, activities, and raising children. Thematic analysis with inductive coding was used to summarize qualitative study findings.ResultsThe ND factor consisted of 12 census-based indicators related to education, employment, ethnicity, housing quality, and age characteristics, but unrelated to home ownership and some ethnicity variables. In multivariable models, ND was associated with greater conduct problems (β = 1.37, p < .05), poor shifting (β = 1.56, p < .01) and emotional control problems (β = 2.36, p < .001). Photovoice and semi-structured interviews yielded four themes: physical disorder, recreation, safety and crime, and community resources. Residents discussed improving waste management and transportation, updating playgrounds, and ensuring neighborhood safety.ConclusionsND in Montevideo comprised a unique set of census indicators. ND was primarily related to behavioral regulation problems. Hypothesized pathways whereby ND affects CBPs are discussed.

Dataset Information

Genetically divergent Francisella philomiragia associated with septic arthritis, Montevideo, Uruguay.

Publications

Genetically divergent <i>Francisella philomiragia</i> associated with septic arthritis, Montevideo, Uruguay.

Similar Datasets

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