Ontology highlight
ABSTRACT:
SUBMITTER: Minaeva M
PROVIDER: S-EPMC10802353 | biostudies-literature | 2024 Jan
REPOSITORIES: biostudies-literature
Minaeva Mariia M Domingo Júlia J Rentzsch Philipp P Lappalainen Tuuli T
bioRxiv : the preprint server for biology 20240101
Understanding the role of transcription and transcription factors in cellular identity and disease, such as cancer and autoimmunity, is essential. However, comprehensive data resources for cell line-specific transcription factor-to-target gene annotations are currently limited. To address this, we developed a straightforward method to define regulons that capture the cell-specific aspects of TF binding and transcript expression levels. By integrating cellular transcriptome and transcription fact ...[more]