Ontology highlight
ABSTRACT:
SUBMITTER: Kushwaha R
PROVIDER: S-EPMC4305010 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Kushwaha Ritu R Jagadish Nirmala N Kustagi Manjunath M Tomishima Mark J MJ Mendiratta Geetu G Bansal Mukesh M Kim Hyunjae R HR Sumazin Pavel P Alvarez Mariano J MJ Lefebvre Celine C Villagrasa-Gonzalez Patricia P Viale Agnes A Korkola James E JE Houldsworth Jane J Feldman Darren R DR Bosl George J GJ Califano Andrea A Chaganti R S K RS
Stem cells (Dayton, Ohio) 20150201 2
The predominant view of pluripotency regulation proposes a stable ground state with coordinated expression of key transcription factors (TFs) that prohibit differentiation. Another perspective suggests a more complexly regulated state involving competition between multiple lineage-specifying TFs that define pluripotency. These contrasting views were developed from extensive analyses of TFs in pluripotent cells in vitro. An experimentally validated, genome-wide repertoire of the regulatory intera ...[more]