Design principles for inflammasome inhibition by pyrin-only-proteins.
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ABSTRACT:
SUBMITTER: Wu S
PROVIDER: S-EPMC10803020 | biostudies-literature | 2024 Jan
REPOSITORIES: biostudies-literature
Publications
Design principles for inflammasome inhibition by pyrin-only-proteins.
Wu Shuai S Garg Archit A Mazanek Zachary Z Belotte Gretchen G Zhou Jeffery J JJ Stallings Christina M CM Lueck Jacob J Roland Aubrey A Chattergoon Michael A MA Sohn Jungsan J
eLife 20240122
Inflammasomes are filamentous signaling platforms essential for host defense against various intracellular calamities such as pathogen invasion and genotoxic stresses. However, dysregulated inflammasomes cause an array of human diseases including autoinflammatory disorders and cancer. It was recently identified that endogenous pyrin-only-proteins (POPs) regulate inflammasomes by directly inhibiting their filament assembly. Here, by combining Rosetta in silico, in vitro, and in cellulo methods, w ...[more]
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