Ontology highlight
ABSTRACT:
SUBMITTER: Cheng Z
PROVIDER: S-EPMC10808187 | biostudies-literature | 2024 Jan
REPOSITORIES: biostudies-literature
Cheng Zhuo Z Huang Maobo M Li Wei W Hou Lei L Jin Li L Fan Qijin Q Zhang Linqiang L Li Chengbin C Zeng Li L Yang Chuanyu C Liang Bin B Li Fubing F Chen Ceshi C
Cell death & disease 20240124 1
The NLRP3 inflammasome plays an important role in protecting the host from infection and aseptic inflammation, and its regulatory mechanism is not completely understood. Dysregulation of NLRP3 can cause diverse inflammatory diseases. HECTD3 is a E3 ubiquitin ligase of the HECT family that has been reported to participate in autoimmune and infectious diseases. However, the relationship between HECTD3 and the NLRP3 inflammasome has not been well studied. Herein, we show that HECTD3 blocks the inte ...[more]