Ontology highlight
ABSTRACT:
SUBMITTER: Li Q
PROVIDER: S-EPMC8811655 | biostudies-literature | 2022 Feb
REPOSITORIES: biostudies-literature
Li Qiang Q Feng Hui H Wang Hongbo H Wang Yinghao Y Mou Wenqing W Xu Guang G Zhang Ping P Li Ruisheng R Shi Wei W Wang Zhilei Z Fang Zhie Z Ren Lutong L Wang Yan Y Lin Li L Hou Xiaorong X Dai Wenzhang W Li Zhiyong Z Wei Ziying Z Liu Tingting T Wang Jiabo J Guo Yuming Y Li Pengyan P Zhao Xu X Zhan Xiaoyan X Xiao Xiaohe X Bai Zhaofang Z
EMBO reports 20211209 2
The activation of the nucleotide oligomerization domain (NOD)-like receptor (NLR) family, pyrin domain-containing protein 3 (NLRP3) inflammasome is related to the pathogenesis of a wide range of inflammatory diseases, but drugs targeting the NLRP3 inflammasome are still scarce. In the present study, we demonstrated that Licochalcone B (LicoB), a main component of the traditional medicinal herb licorice, is a specific inhibitor of the NLRP3 inflammasome. LicoB inhibits the activation of the NLRP3 ...[more]