Ontology highlight
ABSTRACT:
SUBMITTER: Liu H
PROVIDER: S-EPMC10812762 | biostudies-literature | 2023 Dec
REPOSITORIES: biostudies-literature
Liu Honglei H Yu Huiyuan H Gao Rui R Ge Fulin F Zhao Rui R Lu Xia X Wang Tianqi T Liu Huaiwei H Yang Chunyu C Xia Yongzhen Y Xun Luying L
Antioxidants (Basel, Switzerland) 20231222 1
Podophyllotoxin (PTOX) is naturally produced by the plant Podophyllum species. Some of its derivatives are anticancer drugs, which are produced mainly by using chemical semi-synthesis methods. Recombinant bacteria have great potential in large-scale production of the derivatives of PTOX. In addition to introducing the correct enzymes, the transportation of PTOX into the cells is an important factor, which limits its modification in the bacteria. Here, we improved the cellular uptake of PTOX into ...[more]