Ontology highlight
ABSTRACT:
SUBMITTER: Robberts FJ
PROVIDER: S-EPMC1081295 | biostudies-literature | 2005 Mar
REPOSITORIES: biostudies-literature
Robberts F J L FJ Chalkley L J LJ Weyer K K Goussard P P Liebowitz L D LD
Journal of clinical microbiology 20050301 3
Dihydropteroate synthase (DHPS) gene mutations have raised concerns about emerging sulfonamide resistance in Pneumocystis jirovecii. DHPS and dihydrofolate reductase (DHFR) gene products were amplified in clinical specimens from South African patients. One of 53 DHPS genes sequenced contained the double mutation Thr55Ala Pro57Ser. DHFR gene mutations detected were Ala67Val and the new mutations Arg59Gly and C278T. ...[more]